Role of S-adenosylmethionine in preventing cognitive decline…
Cognitive decline is probably something many of us fear as we age. New research suggests that S-adenosylmethionine may play a role in preventing age-related mental decline in both rat and dog models. Well, so far this is only good news for Fido as further studies in humans are necessary to confirm these results.
“These findings confirm that S-adenosyl methionine (SAM) can exert a direct effect on glutathione S-transferase (GST) activity. Since Alzheimer’s disease is accompanied by reduced GST activity, diminished SAM and increased SAH, these findings underscore the critical role of SAM in maintenance of neuronal health” (Tchantchou et al, 2008).
“The aggregate mental impairment score was reduced by more than 50% in 41.2% and 15.8% of dogs treated with SAMe and placebo, respectively, at week 8. SAMe tosylate tablets proved safe and effective in improving signs of age-related mental decline in dogs” (Reme et al, 2008).
References:
Tchantchou F, Graves M, Falcone D, Shea TB. S-Adenosylmethionine Mediates Glutathione Efficacy by Increasing Glutathione S-Transferase Activity: Implications for S-Adenosyl Methionine as A Neuroprotective Dietary Supplement. J Alzheimers Dis. 2008;14(3):323-328.
Reme C, Dramard V, Kern L, Hofmans J, Halsberghe C, Mombiela DV. Effect of s-adenosylmethionine tablets on the reduction of age-related mental decline in dogs: a double-blinded, placebo-controlled trial. Vet Ther. 2008 Summer;9(2):69-82.
alzheimer’s disease s-adenosylmethionine health blog health news cognitive decline nutrition
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I better add it to my normal regimen (before I forget). Very informative. Thanks!